Research Journal of Pharmacy and Technology

C. N. Hemalatha ¹, B. Yeswanth Prasanna Kumar ¹, M. Vijey Anandhi ¹

Affiliations
1 School of Pharmaceutical Sciences, Vels University, Chennai, Tamilnadu, IN

Abstract

Nanotechnology encompass a range of techniques rather than a single discipline and stretches across the whole spectrum of science, touching medicines, physics, engineering and chemistry. Targeted delivery of ingredients to a particular cell type or receptor. Capable of heat triggered local release. Nanoparticles are made up of nonbiodegradable polymers such as methylmethacrylate or it can also be made from biodegradable polymers such as alkylcyano acrylate and albumin. Numerous methods exist for the manufacture of preparation of nanoparticles, allowing extensive modulation of their structure, composition and physiochemical properties. Formulation of nanoparticles of Cefadroxil using Albumin and Eudragit RL 100 in the ratios 1:1 and 1:2. Characterization of nanoparticles and invitro release of drugs has been carried out. In vitro release studies of each polymer was evaluated the synthetic polymer was exhibiting more extended release than natural polymer and the proportion have its influence in extending the release rate of the drug. The half-life of drug using Albumin loaded is 4hr and using Eudragit RL 100 is 4-5hr. Anti-bacterial studies has been done to confirm the anti-bacterial activity.

Keywords

Nanoparticles, Albumin, Eudragit RL 100, Antibacterial.

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C. N. Hemalatha ¹, K. Anbarasu ², M. Vijey Aanandhi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, IN
2 Department of Pharmacology, KMCH College of Pharmacy, Coimbatore, IN

Abstract

Cancer is one of the major diseases and challenging to medicinal system to produce potent and the site specific anti-cancer drugs. In this cancer studies up to now most of the synthetic drugs produce undesirable side effects. At the same time from plant source produce potent and safer anti-cancer drugs than compare to synthetic drugs. Cissus quadrangularis is an important medicinal plant belonging to the family Vitaceae. In this study, the qualitative phytochemical studies by using ethanol and chloroform extracts, Toxicological studies by Acute toxicities studies (LD₅₀), Pharmacological Evaluations of Anti-tumor activity and Biochemical parameters are estimated and Anti-Oxidant Assay of C.quadrangularis were evaluated. The secondary metabolites such as phenol, glycosides, tannins and flavonoids were present in the ethanolic extract of C.quadrangularis. The DMBA breast cancer model is a well-known animal carcinogenesis model. CQ extracts possesses anti-tumor property as evidenced by its significant inhibition in the formation of tumor induced by chemical carcinogen (DMBA). From the results , it can be concluded that chloroform&ethanolic extract of CQ restored the biochemical imbalance occurred due to DMBA administration as well as lowered the tumor incidences and burden, the results obtained with the ethanolic extract were promising as compared to that of chloroform extract. Thus it may be useful for the treatment of mammary carcinoma and associated complications such as oxidative damage.

Keywords

Cissus quadrangularis (CQ), Breast Cancer, 7, 12-dimethylbenz[α]anthracene (DMBA), Anticancer, In-vitro, Phytochemistry.

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